Welcome to the E4N website

The E4N study aims to extend the E3N study by following the descendants of women who participate in the E3N study. The objective is to better understand the onset of disease, from genetics, family environment and the environment outside the family.

Based on the information already collected on 100,000 women E3N, we will supplement the data with some information about fathers, before following the children and grandchildren who will be voluntary.

For these participants we will propose questionnaires, via Internet, the digitization of their health documents and the collection of saliva samples.

This "prospective cohort" was selected under the "Future Investments" program funded by the government for at least 10 years.

The E4N Staff

Founded in 1990, the team INSERM / IGR/ Université Paris-Sud, in charge of the E4N study, includes various talents.

INSERM Research Directors

Françoise Clavel-Chapelon Dr Marie-Christine Boutron Ruault
  • Project Manager

    Pascale Gerbouin-Rérolle
  • Associate Researchers

    Julia Bonastre
    Véronique Chajès
    Blandine De Lauzon-Guillain
    Laure Dossus
    Marina Kvaskoff
    Martin Lajous
    Sylvie Mesrine
    Raphaëlle Varraso
  • Postdoctoral Researchers

    Agnès Fournier
    Nadia Bastide
    Guy Fagherazzi
  • PhD candidates

    Claire Cadeau
    Laureen Dartois
    Laura Nailler
    Florence Perquier
    Antoine Racine
  • Engineers

    Rafika Chaït
    Mélanie Colin
    Maryvonne Niravong
  • IT

    Lyan Hoang
  • Communications

    Camille Laplanche
  • Statisticians

    Anne Bijon
    Aude Lasfargues
    Sébastien Revois
    Émilie Rossignol
    Alice Vilier
  • Data-manager

    Ariane Nasr
    Jessica Pontary
    Maxime Valdenaire
    Fabienne Wilm
  • Project Assistant

    Marie Fangon

Frequently Asked Questions

What does E4N mean?

E4N means "Epidemiology 4 kNowledge". The project is to build an E4N family cohort, involving spouses of the women of E3N, and then enlisting the children and grandchildren of E3N women. E4N main objective is to set-up a prospective family cohort with three generations of participants and create new tools to prevent, diagnose and treat our most common diseases, relying on the well-known E3N cohort experience.

How many people will participate in E4N?

We intend to follow approximately 50,000 children of the 170,000 E3N children (ie, 1.7 children per woman). The first generation children will be followed along with their spouses and then their children, i.e. the grandchildren of E3N women. In total, the study should cover several hundreds of thousands of people.

How long will the Study last?

Funding has been provided for 10 years. After 10 years, the study will probably continue because this cohort is unique in France and provide many applications.

What are the expected results and outcomes?

We are expecting results concerning:
  • the causes of occurrence of major diseases. The effect of smoking or nutrition is already well known, thus we will try to collect data on stress, pollution... to clarify the role of various factors (electromagnetic fields, heavy metals, vaccines…) on the onset of diseases.
  • the effect of drugs and 'pharmacovigilance'. Remind that the E3N cohort studied the impact of different hormone treatments on the risk of breast cancer.
  • tools to better understand disease prevention: medical software to assess individual risk before proposing a treatment or preventive screening based on estimated risks.

What were the results of E3N?

To learn more about the scientific results of the E3N cohort, we invite you to visit the E3N website: www.e3n.fr

Who is funding the project?

This project is funded exclusively by the French Government under "Investments for the future." Specifically, it is the National Agency of Research (ANR) which manages the funds, the latter being paid to the Université Paris-Sud, institutional bearer of the project.

Partenaires

The E4N study, labeled “Investment for the future”, is supported by several partners:

How to participate

If you are the child of a woman participating in the E3N study, you can leave us your email address to be contacted for the first E4N questionnaire. By submitting your email address, it does not imply any commitment on your part:



Frequently Asked Questions

What does E4N mean?

E4N means "Epidemiology 4 kNowledge". The project is to build an E4N family cohort, involving spouses of the women of E3N, and then enlisting the children and grandchildren of E3N women. E4N main objective is to set-up a prospective family cohort with three generations of participants and create new tools to prevent, diagnose and treat our most common diseases, relying on the well-known E3N cohort experience.

How many people will participate in E4N?

We intend to follow approximately 50,000 children of the 170,000 E3N children (ie, 1.7 children per woman). The first generation children will be followed along with their spouses and then their children, i.e. the grandchildren of E3N women. In total, the study should cover several hundreds of thousands of people.

How long will the Study last?

Funding has been provided for 10 years. After 10 years, the study will probably continue because this cohort is unique in France and provide many applications.

What are the expected results and outcomes?

We are expecting results concerning:
  • the causes of occurrence of major diseases. The effect of smoking or nutrition is already well known, thus we will try to collect data on stress, pollution... to clarify the role of various factors (electromagnetic fields, heavy metals, vaccines…) on the onset of diseases.
  • the effect of drugs and 'pharmacovigilance'. Remind that the E3N cohort studied the impact of different hormone treatments on the risk of breast cancer.
  • tools to better understand disease prevention: medical software to assess individual risk before proposing a treatment or preventive screening based on estimated risks.

What were the results of E3N?

To learn more about the scientific results of the E3N cohort, we invite you to visit the E3N website: www.e3n.fr

Who is funding the project?

This project is funded exclusively by the French Government under "Investments for the future." Specifically, it is the National Agency of Research (ANR) which manages the funds, the latter being paid to the Université Paris-Sud, institutional bearer of the project.

E4N team, in collaboration with AFCROs, and in partnership with ITMO Santé Publique, Inria, Cap Digital, Systematic, Medicen and TIC & Santé, is organizing an international conference the 21st May 2013, at the Cité Internationale Universitaire, Paris 14 (France).

Goal:
To present academic research and industrial innovations based on ICT (Information and Communication) pertinent to epidemiological research.

Topics discussed:

  • Recruiting and involving volunteers in a cohort via social networks,
  • Collecting data via web questionnaires,
  • Collecting data from participants on their lifestyle, environment and health using innovative tools.

Organization:
Oral scientific presentations, sessions on emergence of e-tools, stands for showcasing tools.

Conference goals

Systematic collection of data on lifestyle and health, as well as participation and long-term adherence on the part of a large number of volunteers, are crucial to any epidemiological study. Traditional methods, such as face-to-face and telephone interviews or self-administered questionnaires, fail to produce acceptable qualitative results and are very costly.

In this era of "Quantified Self", phenomenon that consists of measuring and analyzing one’s own personal data, and social networks of patients, tools for recruiting, monitoring and collecting data need to be adapted to the lifestyle of today’s population, which has less and less free time and is making use of more innovative technologies in everyday life. Internet and smartphones provide a powerful alternative for data collection, with specificities that remain largely unexplored.

The Inserm team (UMRS 1018, Team 9), headed by Françoise Clavel-Chapelon and financed by the Avenir Investments Program to implement the E4N cohort, is organizing an international conference the goal of which is to bring together actors from different academic and industrial fields to discuss the emergence of innovative methods and tools for:

  • Recruiting and involving a maximum of volunteers in a cohort,
  • Ensuring adherence of these volunteers via social networks,
  • Collecting data from participants on their lifestyle, environment and health in a manner that is recreational and non-restrictive.

This conference will be a state of the art of new tools from various fields such as mobility, social networks, e-health or space technology, which can now find applications in the field of e-epidemiology. It will thus highlight novel technologies which can improve the management of epidemiological cohorts such as E4N.

The convergence of these technological developments with epidemiology opens new perspectives for enhancing prevention strategies, improving the efficiency of public health recommendations, and ultimately, improving population health.

Programme

Click here to download the Programme

Click on blue links to download slides !

9:00

Françoise Clavel-Chapelon (France)

Inserm – University Paris-Sud – Institut Gustave Roussy : UMRS 1018, team 9

Studies in the general population: the E3N and E4N cohorts

9:20

Fabrice Beauchêne (France)

AFCROs (Association française des CROs)

Association of French Clinical and Epidemiological Research Service Providers

9:30

John Dennis Wark (Australia)

Royal Melbourne Hospital

Social Media as a Tool for Recruiting Young Women into Health Studies

10:00

Nancy Pedersen (Sweden)

Karolinska Institutet

The LifeGene Cohort: An example of efficient use of e-tools in large, prospective cohort studies

11:00

Carol Boushey (USA)

Department of Nutrition Science, Purdue University

Epidemiology Program, University of Hawaii Cancer Center

Leveraging technology to enhance dietary assessment

11:30-12:30

Session emergence of e-tools:

1. Erard le Beau de Hemricourt and Mitchell Silva: Esperity

2. John Dennis Wark: Safe-D Study

3. Suzanne Garland: SenseWear Armband (SWA)

4. Genevieve Dunton: Ecological Momentary Assessment (EMA)

5. Lenore Arab: DietDay2

6. Frédéric Durand-Salmon: BePATIENT

14:00

Stephen Intille (USA)

Department of Computer and Information Science, Northeastern University, Boston

Using Mobile Phones for Measurement of Physical Activity and Health Behaviors

14:30

Aiden Roger Doherty (Ireland)

CLARITY: Centre for Sensor Web Technologies, Dublin City University

Using wearable cameras to recognise a range of lifestyle health-related behaviours

15:00

John Nuckols (USA)

Dpt of environmental and radiological Health Sciences, Colorado State University

Integrating geospatial and environmental sciences into exposure assessment for epidemiological risk analysis

16:00-17:00

Session emergence of e-tools:

1. Michel Seiler (Orange Healthcare): Voices

2. Stéphane Schück: Kappa Santé

3. Yoani Matsakis (Telemedicine Technologies): CleanWeb ePRO

4. Ronan de Fresnoy (Popsi Cube) and Isabelle Lauret (Body Cap): e-Temp

5. Yan Kestens: Study Management Application, VERITAS and a Multisensor platform

6. Samuel Nowakowski (Loria) and Régis Lhoste (Sailendra): Détermination et animation automatique de communautés virtuelles dans des réseaux de grande taille

17:00

Robert Picard (France)
CGEIET – Ministry of Economy

Conclusion

Moderators:      Philippe Gesnouin (France)
Healthcare, life sciences, biotechnology Associate- Technology Transfert and Innovation department - Inria

                       Basile Chaix (France)
                      
Inserm Researcher- UMR-S 707 (Inserm - UPMC)

Partners
Organizers:
 
 
Partners:
 
 
Under the auspices of:
 
Sponsors :
Practical information

The conference will take place in the auditorium Adenaueur, located at the 1st floor of the main building of the Cité Internationale Universitaire of Paris

Adresse :
Auditorium Adenauer
Cité Internationale Universitaire of Paris
17, boulevard Jourdan
75014 Paris
France

Access and parking :
RER B and tramway T3 – Cité Universitaire Station
Metro line 4 – Porte d’Orléans Station
Bus 21, 88, 67 – Cité Universitaire Stop
Vélib’ station in front of the Cité internationale
Ring road: exit at Porte d’Orléans or Porte de Gentilly
Public parking nearby: Charlety, 400 places

Contact

For any questions concerning:

Please send an e-mail to:

General organization

camille.laplanche@igr.fr

Stand booking / Registrations

v.marty@afcros.com

Emergence of e-tools / Programme

colloque.E4N@gmail.com


Contact Us

If you have any questions or comments about the Web site, or about the Study in general, feel free to contact us:

INSERM Unité 1018 - Équipe 9

Institut Gustave Roussy
114 rue Édouard Vaillant
94805 Villejuif Cedex

Head of the lab

Françoise Clavel-Chapelon

Secretary

Phone : 01 42 11 53 86
Fax : 01 42 11 40 00